TEN DRUGS
by Thomas Hager is subtitled “How
Plants, Powders, and Pills Have Shaped the History of Medicine” and Hager
writes about both breakthroughs and unintended consequences of experimentation
and development. In his Introduction, he stresses that “No drug is good. No
drug is bad. Every drug is both.” Leaving out more well-known drugs like
penicillin and aspirin, Hager uses each of ten separate chapters to highlight the
history of a drug (like CPZ, the first antipsychotic) or family of drugs (like statins),
writing “my preference is for lively stories and memorable characters.” For
example, one chapter briefly covers efforts through the 1930s to isolate the
hormone progesterone, outlines the continued research in the 1950s with support
from Margaret Sanger and Katharine McCormick, and touches upon restraints from
local laws and possible ethical concerns with regard to informed consent of
patients. Hager then notes, “by 1967 [after FDA approval], thirteen million women
around the world had taken some form of the Pill. The number of users today,
with greatly improved formulations, tops one hundred million.” Other chapters
discuss opium, vaccines (especially smallpox), or chloral hydrate (knock-out
drops). His summaries are indeed brief and readers will want to explore
elsewhere for more details; what I found amazing, though, is our relative
ignorance – even thirty years ago – about how some systems in the body work and
therefore about how drugs might interact. TEN
DRUGS received a starred review from Kirkus which commented
also about how “nowadays, lifesaving drugs attract less attention than those
that improve the quality of life.”
DRUGS, MONEY, AND SECRET HANDSHAKES
by Robin Feldman is subtitled “The
Unstoppable Growth of Prescription Drug Prices.” Feldman is a Professor of Law
at the University of California Hastings and has written other books about the
intersection of science and law, including ones which focus on patent law and
drug pricing strategies. In her latest text, she documents the “high cost of
brand medications for common conditions,” and the extent to which government
budgets are “struggling to cover the cost of new, expensive medicines.” She argues that “internal incentives push
every market participant towards behaviors that increase prices, knocking out
the normal checks that should operate as brake-points on the market.” After
background information on the market and the effects of rising prices, she uses
subsequent chapters to explain how incentive structures for insurance
companies, pharmacies, doctors and patient groups drive prices higher. Another
chapter looks at drug company efforts to keep out lower priced competitors. And,
finally, she suggests some changes for “realigning the industry’s incentives
with society’s interests.”
Feldman addresses an extremely complex topic and
provides a much needed overview for policy makers, although this seems quite complex
(e.g., while some changes would seem to increase competition they may move
oversight from a Federal to a State level) even for those of our students who are very
interested in the impact and power of the pharmaceutical industry. DRUGS, MONEY, AND SECRET HANDSHAKES
contains truly extensive notes (more than a third of this roughly two-hundred page
book), plus a helpful index and several diagrams.